Veterinary Vaccine: Discovery/Feasibility

Bottlenecks in the process are marked with a B.

All are standard proces unless stated otherwise.

  1. Livestock or companion animal host immunology B
    1. Ethical Approval
  2. Pathogen Biology B
  3. Pathogen challenge model (Optional) B
    1. Ethical approval B
  4. Antigen discovery and immunogen design (SUBMAP)
    1. Vaccine type
      1. Whole antigen (Viral, Bacterial, Parasite)
        1. Growth rate. Manufacture, Attenuated or inactivated, Adjuvant/delivery
      2.  Nucleic Acid, VLP, Subunit, Vectored, Glycoconjugate
        1. Antigen selection and purification
        2. Antigen/gene of interest, Vaccine vector, Adjuvant, Delivery System
    2. Proceed to in vitro/in vivo studies
  5. Pre-formulation work
  6. In vitro studies
  7. Early in vivo
  8. Challenge model with antigen(s) B
    1. Ethical approval
  9. Analysis of immune response – correlates of protection data (If favourable continue to Steps 11, if unfavourable go back to Step 4)
  10. Immunisation strategy
  11. Lead(s) identification
    1. Freedom to operate B
    2. Patent application

Ongoing  throughout  process:

Next list view of map – Early-phase Development Map

Underlined nodes have further information and can be selected. Those using assistive technologies can access the full information using the list view of the map.

discovery routemap Go to animal regulatory affairs. Go to animal regulatory affairs. Go to animal regulatory affairs. Veterinary Target product profile. Go to animal early phase development. Go to animal regulatory affairs. Go to animal Antigen discovery and Immunogen design submap.